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HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis

Spontaneous or treatment induced seroconversion in chronic HBV infection is rare and generation of anti-HBs antibodies is the current goal of HBV therapeutics. Here we investigated B and follicular T helper (Tfh) cell defects that persist in HBV infection despite long-term nucleos(t)ide analog (NUC)...

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Detalles Bibliográficos
Autores principales: Poonia, Bhawna, Ayithan, Natarajan, Nandi, Madhuparna, Masur, Henry, Kottilil, Shyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193006/
https://www.ncbi.nlm.nih.gov/pubmed/30333570
http://dx.doi.org/10.1038/s41598-018-33719-x