Cargando…

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness

Glioblastoma is a highly malignant tumor that easily acquires resistance to treatment. The stem-cell-like character (stemness) has been thought to be closely associated with the treatment resistance of glioblastoma cells. In this study, we determined that farnesyl diphosphate synthase (FDPS), a key...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hee Yeon, Kim, Dong Keon, Bae, Seung-Hyun, Gwak, HyeRan, Jeon, Ji Hoon, Kim, Jong Kwang, Lee, Byung Il, You, Hye Jin, Shin, Dong Hoon, Kim, Young-Ho, Kim, Soo Youl, Han, Sung-Sik, Shim, Jin-Kyoung, Lee, Ji-Hyun, Kang, Seok-Gu, Jang, Hyonchol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193020/ https://www.ncbi.nlm.nih.gov/pubmed/30333528 http://dx.doi.org/10.1038/s12276-018-0166-2

Ejemplares similares

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma
por: Abate, Mario, et al.
Publicado: (2017)

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
por: Gabriel, Heloisa B, et al.
Publicado: (2018)

Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants
por: Guo, Dong, et al.
Publicado: (2015)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
por: Ha, Nguyen Thi, et al.
Publicado: (2020)

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres
por: Kim, Hee Yeon, et al.
Publicado: (2019)

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
por: Jordão, Fabiana M, et al.
Publicado: (2013)

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
por: Ory, B, et al.
Publicado: (2008)

Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus
por: Samori, Petrus Yesaya, et al.
Publicado: (2017)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
por: Gong, Daoyong, et al.
Publicado: (2022)

Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues
por: Hou, Anwei, et al.
Publicado: (2021)

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes
por: Zhang, Dongrui, et al.
Publicado: (2023)

Biosynthesis of α-Bisabolol by Farnesyl Diphosphate Synthase and α-Bisabolol Synthase and Their Related Transcription Factors in Matricaria recutita L.
por: Tai, Yuling, et al.
Publicado: (2023)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase
por: Chan, Yueh-Te, et al.
Publicado: (2017)

Photosynthetic conversion of CO(2) to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria
por: Choi, Sun Young, et al.
Publicado: (2016)

Cloning and Characterization of Farnesyl Diphosphate Synthase Gene Involved in Triterpenoids Biosynthesis from Poria cocos
por: Wang, Jianrong, et al.
Publicado: (2014)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
por: Jin, Tingting, et al.
Publicado: (2022)

Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells
por: Wang, Lijuan, et al.
Publicado: (2023)

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia
por: Gadelha, Ana Paula R., et al.
Publicado: (2020)

Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
por: Jeon, Ji Hoon, et al.
Publicado: (2016)

Concise synthesis of artemisinin from a farnesyl diphosphate analogue
por: Tang, Xiaoping, et al.
Publicado: (2018)

Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum
por: Nuttall, James M., et al.
Publicado: (2012)

Sesquiterpene Synthase‐Catalysed Formation of a New Medium‐Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues
por: Huynh, Florence, et al.
Publicado: (2018)

Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells
por: Oike, Asami, et al.
Publicado: (2022)

A cytosolic bifunctional geranyl/farnesyl diphosphate synthase provides MVA-derived GPP for geraniol biosynthesis in rose flowers
por: Conart, Corentin, et al.
Publicado: (2023)

Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum
por: Fei, Yu, et al.
Publicado: (2019)

Rational design of Lepidoptera-specific insecticidal inhibitors targeting farnesyl diphosphate synthase, a key enzyme of the juvenile hormone biosynthetic pathway
por: Picard, Marie-Ève, et al.
Publicado: (2021)

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
por: Pan, Jian-Jung, et al.
Publicado: (2015)

Inhibition of Coenzyme Qs Accumulation in Engineered Escherichia coli by High Concentration of Farnesyl Diphosphate
por: Samoudi, Mojtaba, et al.
Publicado: (2015)

Inhibitory Effects of Hwangryunhaedok-Tang in 3T3-L1 Adipogenesis by Regulation of Raf/MEK1/ERK1/2 Pathway and PDK1/Akt Phosphorylation
por: Kwak, Dong Hoon, et al.
Publicado: (2013)

Primary Glioblastoma of the Cerebellopontine Angle: Case Report and Review of the Literature
por: Lee, Ji-Hye, et al.
Publicado: (2017)

Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies
por: Kang, Hyunkoo, et al.
Publicado: (2022)

Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats
por: Lee, Sun Min, et al.
Publicado: (2017)

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models
por: Liou, Mei-Ling, et al.
Publicado: (2022)

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
por: Agabiti, Sherry S., et al.
Publicado: (2019)

Regulation of mRNA export through API5 and nuclear FGF2 interaction
por: Bong, Seoung Min, et al.
Publicado: (2020)

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
por: Dehghani, Mehdi, et al.
Publicado: (2018)

Genetic Polymorphism of Geranylgeranyl Diphosphate Synthase (GGSP1) Predicts Bone Density Response to Bisphosphonate Therapy in Korean Women
por: Choi, Hyung Jin, et al.
Publicado: (2010)

Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase
por: Ohno, K, et al.
Publicado: (2011)

O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells
por: Kim, Dong Keon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d2giauu736b856tl168m67c482