TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations

TERT promoter (TERTp) mutations are found in the majority of World Health Organization (WHO) grade IV adult IDH wild-type glioblastoma (IDH-wt GBM). Here, we characterized the subset of IDH-wt GBMs that do not have TERTp mutations. In a cohort of 121 adult grade IV gliomas, we identified 109 IDH-wt...

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Detalles Bibliográficos
Autores principales: Williams, Erik A., Miller, Julie J., Tummala, Shilpa S., Penson, Tristan, Iafrate, A. John, Juratli, Tareq A., Cahill, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193287/
https://www.ncbi.nlm.nih.gov/pubmed/30333046
http://dx.doi.org/10.1186/s40478-018-0613-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193287/
https://www.ncbi.nlm.nih.gov/pubmed/30333046
http://dx.doi.org/10.1186/s40478-018-0613-2

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