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TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations

TERT promoter (TERTp) mutations are found in the majority of World Health Organization (WHO) grade IV adult IDH wild-type glioblastoma (IDH-wt GBM). Here, we characterized the subset of IDH-wt GBMs that do not have TERTp mutations. In a cohort of 121 adult grade IV gliomas, we identified 109 IDH-wt...

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Detalles Bibliográficos
Autores principales:	Williams, Erik A., Miller, Julie J., Tummala, Shilpa S., Penson, Tristan, Iafrate, A. John, Juratli, Tareq A., Cahill, Daniel P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193287/ https://www.ncbi.nlm.nih.gov/pubmed/30333046 http://dx.doi.org/10.1186/s40478-018-0613-2

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