mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances

The 5′ and 3′ termini of RNA play important roles in many cellular processes. Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have an intrinsic propensity to fold in the absence of proteins into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of...

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Detalles Bibliográficos
Autores principales: Lai, Wan-Jung C., Kayedkhordeh, Mohammad, Cornell, Erica V., Farah, Elie, Bellaousov, Stanislav, Rietmeijer, Robert, Salsi, Enea, Mathews, David H., Ermolenko, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193969/
https://www.ncbi.nlm.nih.gov/pubmed/30337527
http://dx.doi.org/10.1038/s41467-018-06792-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193969/
https://www.ncbi.nlm.nih.gov/pubmed/30337527
http://dx.doi.org/10.1038/s41467-018-06792-z

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