Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease

Missense mutations in glucocerebrosidase (GBA1) that impair the activity of the encoded lysosomal lipid metabolism enzyme (GCase) are linked to an increased risk of Parkinson’s disease. However, reduced GCase activity is also found in brain tissue from Parkinson’s disease patients without GBA1 mutat...

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Detalles Bibliográficos
Autores principales: Atashrazm, Farzaneh, Hammond, Deborah, Perera, Gayathri, Dobson-Stone, Carol, Mueller, Nicole, Pickford, Russell, Kim, Woojin Scott, Kwok, John B., Lewis, Simon J. G., Halliday, Glenda M., Dzamko, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193988/
https://www.ncbi.nlm.nih.gov/pubmed/30337601
http://dx.doi.org/10.1038/s41598-018-33921-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193988/
https://www.ncbi.nlm.nih.gov/pubmed/30337601
http://dx.doi.org/10.1038/s41598-018-33921-x

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