Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in disea...

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Detalles Bibliográficos
Autores principales: Ochieng, Pius, Nath, Sridesh, Macarulay, Reane, Eden, Edward, Dabo, Abdoulaye, Campos, Michael, Jiang, Xian-Cheng, Foronjy, Robert F., Geraghty, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193999/
https://www.ncbi.nlm.nih.gov/pubmed/30337619
http://dx.doi.org/10.1038/s41598-018-33851-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193999/
https://www.ncbi.nlm.nih.gov/pubmed/30337619
http://dx.doi.org/10.1038/s41598-018-33851-8

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