Cargando…

Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Ochieng, Pius, Nath, Sridesh, Macarulay, Reane, Eden, Edward, Dabo, Abdoulaye, Campos, Michael, Jiang, Xian-Cheng, Foronjy, Robert F., Geraghty, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193999/
https://www.ncbi.nlm.nih.gov/pubmed/30337619
http://dx.doi.org/10.1038/s41598-018-33851-8