Cargando…

Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in disea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ochieng, Pius, Nath, Sridesh, Macarulay, Reane, Eden, Edward, Dabo, Abdoulaye, Campos, Michael, Jiang, Xian-Cheng, Foronjy, Robert F., Geraghty, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193999/ https://www.ncbi.nlm.nih.gov/pubmed/30337619 http://dx.doi.org/10.1038/s41598-018-33851-8

Ejemplares similares

Cigarette smoke exposure reduces leukemia inhibitory factor levels during respiratory syncytial viral infection
por: Poon, Justin, et al.
Publicado: (2019)

Elevated levels of calpain 14 in nasal tissue in chronic rhinosinusitis
por: Boruk, Marina, et al.
Publicado: (2020)

Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations
por: Foronjy, Robert F., et al.
Publicado: (2016)

C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency
por: Fee, Laura T., et al.
Publicado: (2021)

Elevated S100A9 expression in chronic rhinosinusitis coincides with elevated MMP production and proliferation in vitro
por: Boruk, Marina, et al.
Publicado: (2020)

Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection
por: Foronjy, Robert F, et al.
Publicado: (2014)

Mechanisms of Degranulation in Neutrophils
por: Lacy, Paige
Publicado: (2006)

Should we worry about children's exposure to third-hand by-products generated from electronic nicotine delivery systems?
por: Nath, Sridesh, et al.
Publicado: (2020)

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
por: Janciauskiene, Sabina, et al.
Publicado: (2018)

Respiratory Syncytial Virus Infections Enhance Cigarette Smoke Induced COPD in Mice
por: Foronjy, Robert F., et al.
Publicado: (2014)

Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner
por: Garcia-Arcos, Itsaso, et al.
Publicado: (2016)

Neutrophil degranulation and myocardial infarction
por: Zhang, Nan, et al.
Publicado: (2022)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis
por: Borhanjoo, Panid, et al.
Publicado: (2021)

STAT3 modulates cigarette smoke-induced inflammation and protease expression
por: Geraghty, Patrick, et al.
Publicado: (2013)

Type I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors
por: Foronjy, Robert F., et al.
Publicado: (2014)

α1-antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophil-conditioned medium on lung cancer HCC cells, in vitro
por: Zelvyte, Inga, et al.
Publicado: (2004)

Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus
por: Dabo, Abdoulaye J., et al.
Publicado: (2015)

Does Augmentation with Alpha1-Antitrypsin Affect Neutrophil Extracellular Traps Formation?
por: Frenzel, Eileen, et al.
Publicado: (2012)

The impact of endoplasmic reticulum stress on neutrophil function in alpha 1 antitrypsin deficiency
por: Shaharom, M, et al.
Publicado: (2015)

Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils
por: Lee, Jungnam, et al.
Publicado: (2020)

The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
por: Lodge, Katharine M., et al.
Publicado: (2020)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)
por: Agudelo, Christina W., et al.
Publicado: (2020)

Alpha-1 Antitrypsin Deficiency: Does Increased Neutrophil Adhesion Contribute to Lung Damage?
por: Prendecki, Maria, et al.
Publicado: (2022)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

The Biological Effects of Double-Dose Alpha-1 Antitrypsin Augmentation Therapy. A Pilot Clinical Trial
por: Campos, Michael A., et al.
Publicado: (2019)

HCK promotes glioblastoma progression by TGFβ signaling
por: Wang, Zhenlin, et al.
Publicado: (2020)

Hypoxia upregulates neutrophil degranulation and potential for tissue injury
por: Hoenderdos, Kim, et al.
Publicado: (2016)

Zinc Supplementation Modulates NETs Release and Neutrophils’ Degranulation
por: Kuźmicka, Weronika, et al.
Publicado: (2020)

Manipulating neutrophil degranulation as a bacterial virulence strategy
por: Eichelberger, Kara R., et al.
Publicado: (2020)

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals
por: Dunlea, Danielle M, et al.
Publicado: (2018)

Hypoxia Enhances Oxidative Stress in Neutrophils from ZZ Alpha-1 Antitrypsin Deficiency Patients
por: Magallón, María, et al.
Publicado: (2023)

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function
por: Hudock, K. M., et al.
Publicado: (2023)

Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus
por: Park, Sangmi S., et al.
Publicado: (2021)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst
por: Kowanko, I. C., et al.
Publicado: (1993)

Quercetin inhibits degranulation and superoxide generation in PMA stimulated neutrophils
por: Pečivová, Jana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_icp4ce9pahn631ktgrqvoqspkq