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Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in disea...

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Detalles Bibliográficos
Autores principales:	Ochieng, Pius, Nath, Sridesh, Macarulay, Reane, Eden, Edward, Dabo, Abdoulaye, Campos, Michael, Jiang, Xian-Cheng, Foronjy, Robert F., Geraghty, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193999/ https://www.ncbi.nlm.nih.gov/pubmed/30337619 http://dx.doi.org/10.1038/s41598-018-33851-8

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