Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates

Extensive mannose trimming of nascent glycoprotein N-glycans signals their targeting to endoplasmic reticulum-associated degradation (ERAD). ER mannosidase I (ERManI) and the EDEM protein family participate in this process. However, whether the EDEMs are truly mannosidases can be addressed only by m...

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Detalles Bibliográficos
Autores principales: Shenkman, Marina, Ron, Efrat, Yehuda, Rivka, Benyair, Ron, Khalaila, Isam, Lederkremer, Gerardo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194124/
https://www.ncbi.nlm.nih.gov/pubmed/30374462
http://dx.doi.org/10.1038/s42003-018-0174-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194124/
https://www.ncbi.nlm.nih.gov/pubmed/30374462
http://dx.doi.org/10.1038/s42003-018-0174-8

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