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Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast‐immobilized mouse hindlimb

We recently reported results showing that cast immobilization of a rat hindlimb rapidly leads to development of anabolic resistance as demonstrated by failure of oral leucine administration to activate the mechanistic target of rapamycin complex 1 (mTORC1) and stimulate protein synthesis in the sole...

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Detalles Bibliográficos
Autores principales: Shimkus, Kevin L., Jefferson, Leonard S., Gordon, Bradley S., Kimball, Scot R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194210/
https://www.ncbi.nlm.nih.gov/pubmed/30338657
http://dx.doi.org/10.14814/phy2.13891