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Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos

BACKGROUND: Recent technological development allows nearly complete replacement of the cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria (mutated mitochondrial DNA: mtDNA) for patients with inherited mitochondrial diseases, which is called mitochondrial replac...

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Detalles Bibliográficos
Autores principales:	Tachibana, Masahito, Kuno, Takashi, Yaegashi, Nobuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194288/ https://www.ncbi.nlm.nih.gov/pubmed/30377395 http://dx.doi.org/10.1002/rmb2.12230

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