Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light

[Image: see text] Selectivity remains a major challenge in anticancer therapy, which potentially can be overcome by local activation of a cytotoxic drug. Such triggered activation can be obtained through modification of a drug with a photoremovable protecting group (PPG), and subsequent irradiation...

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Detalles Bibliográficos
Autores principales: Hansen, Mickel J., Feringa, Femke M., Kobauri, Piermichele, Szymanski, Wiktor, Medema, René H., Feringa, Ben L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194649/
https://www.ncbi.nlm.nih.gov/pubmed/30284823
http://dx.doi.org/10.1021/jacs.8b04870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194649/
https://www.ncbi.nlm.nih.gov/pubmed/30284823
http://dx.doi.org/10.1021/jacs.8b04870

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