Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

BACKGROUND: Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance at the BBB. The cellular and molecular mecha...

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Detalles Bibliográficos
Autores principales: Ma, Qingyi, Zhao, Zhen, Sagare, Abhay P, Wu, Yingxi, Wang, Min, Owens, Nelly Chuqui, Verghese, Philip B, Herz, Joachim, Holtzman, David M, Zlokovic, Berislav V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194676/
https://www.ncbi.nlm.nih.gov/pubmed/30340601
http://dx.doi.org/10.1186/s13024-018-0286-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194676/
https://www.ncbi.nlm.nih.gov/pubmed/30340601
http://dx.doi.org/10.1186/s13024-018-0286-0

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