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Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin
Low expression and instability are significant challenges in the recombinant production of therapeutic peptides. The current study introduces a novel expression and purification system for human insulin production using the molecular chaperone αB-crystallin (αB-Cry) as a fusion partner protein. Insu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195290/ https://www.ncbi.nlm.nih.gov/pubmed/30339677 http://dx.doi.org/10.1371/journal.pone.0206169 |