The double stranded RNA analog poly-IC elicits both robust IFN-λ production and oncolytic activity in human gastrointestinal cancer cells

PURPOSE: Type III IFN (IFN-λ) is the dominant frontline response over type I IFN in human normal intestinal epithelial cells upon viral infection, this response being mimicked by the dsRNA analog poly-IC. Poly-IC also induces cell death in murine intestinal crypts ex vivo. Here we examined whether t...

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Detalles Bibliográficos
Autores principales: Bou-Hanna, Chantal, Jarry, Anne, Mosnier, Jean-François, Bossard, Céline, Laboisse, Christian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195374/
https://www.ncbi.nlm.nih.gov/pubmed/30349642
http://dx.doi.org/10.18632/oncotarget.26121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195374/
https://www.ncbi.nlm.nih.gov/pubmed/30349642
http://dx.doi.org/10.18632/oncotarget.26121

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