Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicating many potential targets. Based on a 1.9 Å resolu...

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Detalles Bibliográficos
Autores principales: Andersen, Jacob Lauwring, Gesser, Borbala, Funder, Erik Daa, Nielsen, Christine Juul Fælled, Gotfred-Rasmussen, Helle, Rasmussen, Mads Kirchheiner, Toth, Rachel, Gothelf, Kurt Vesterager, Arthur, J. Simon C., Iversen, Lars, Nissen, Poul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195510/
https://www.ncbi.nlm.nih.gov/pubmed/30341347
http://dx.doi.org/10.1038/s41467-018-06787-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195510/
https://www.ncbi.nlm.nih.gov/pubmed/30341347
http://dx.doi.org/10.1038/s41467-018-06787-w

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