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Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicating many potential targets. Based on a 1.9 Å resolu...
Autores principales: | Andersen, Jacob Lauwring, Gesser, Borbala, Funder, Erik Daa, Nielsen, Christine Juul Fælled, Gotfred-Rasmussen, Helle, Rasmussen, Mads Kirchheiner, Toth, Rachel, Gothelf, Kurt Vesterager, Arthur, J. Simon C., Iversen, Lars, Nissen, Poul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195510/ https://www.ncbi.nlm.nih.gov/pubmed/30341347 http://dx.doi.org/10.1038/s41467-018-06787-w |
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