Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study reveals that P1-HNF4α, the predominant isoform expressed in the adult liver, inhibits expression of tumor promoting...

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Detalles Bibliográficos
Autores principales: Fekry, Baharan, Ribas-Latre, Aleix, Baumgartner, Corrine, Deans, Jonathan R., Kwok, Christopher, Patel, Pooja, Fu, Loning, Berdeaux, Rebecca, Sun, Kai, Kolonin, Mikhail G., Wang, Sidney H., Yoo, Seung-Hee, Sladek, Frances M., Eckel-Mahan, Kristin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195513/
https://www.ncbi.nlm.nih.gov/pubmed/30341289
http://dx.doi.org/10.1038/s41467-018-06648-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195513/
https://www.ncbi.nlm.nih.gov/pubmed/30341289
http://dx.doi.org/10.1038/s41467-018-06648-6

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