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Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study reveals that P1-HNF4α, the predominant isoform expressed in the adult liver, inhibits expression of tumor promoting...
Autores principales: | Fekry, Baharan, Ribas-Latre, Aleix, Baumgartner, Corrine, Deans, Jonathan R., Kwok, Christopher, Patel, Pooja, Fu, Loning, Berdeaux, Rebecca, Sun, Kai, Kolonin, Mikhail G., Wang, Sidney H., Yoo, Seung-Hee, Sladek, Frances M., Eckel-Mahan, Kristin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195513/ https://www.ncbi.nlm.nih.gov/pubmed/30341289 http://dx.doi.org/10.1038/s41467-018-06648-6 |
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