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A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor

Based on a molecular classification of prostate cancer using gene expression pathway signatures, we derived a set of 48 genes in critical pathways that significantly predicts clinical outcome in all tested patient cohorts. We tested these genes in a functional genomics screen in a panel of three pro...

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Detalles Bibliográficos
Autores principales: Hewit, Kay, Sandilands, Emma, Martinez, Rafael Sanchez, James, Daniel, Leung, Hing Y., Bryant, David M., Shanks, Emma, Markert, Elke K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195526/
https://www.ncbi.nlm.nih.gov/pubmed/30341281
http://dx.doi.org/10.1038/s41419-018-1115-7