Cargando…

Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

Genome-wide association studies (GWAS) aim to identify genetic factors associated with phenotypes. Standard analyses test variants for associations individually. However, variant-level associations are hard to identify and can be difficult to interpret biologically. Enrichment analyses help address...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xiang, Stephens, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195536/ https://www.ncbi.nlm.nih.gov/pubmed/30341297 http://dx.doi.org/10.1038/s41467-018-06805-x

Ejemplares similares

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
por: Namjou, Bahram, et al.
Publicado: (2019)

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
por: Scott, Robert A, et al.
Publicado: (2012)

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
por: Han, Xikun, et al.
Publicado: (2023)

Genome-wide imputed differential expression enrichment analysis identifies trait-relevant tissues
por: Ghaffar, Ammarah, et al.
Publicado: (2023)

Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy
por: Tadros, Rafik, et al.
Publicado: (2023)

A Large-Scale Genome-Wide Association Analyses of Ethiopian Sorghum Landrace Collection Reveal Loci Associated With Important Traits
por: Girma, Gezahegn, et al.
Publicado: (2019)

Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits
por: Grotzinger, Andrew D., et al.
Publicado: (2022)

Network- and enrichment-based inference of phenotypes and targets from large-scale disease maps
por: Hoch, Matti, et al.
Publicado: (2022)

Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle
por: Xiang, Ruidong, et al.
Publicado: (2017)

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits
por: Evans, Luke M., et al.
Publicado: (2023)

Genome-wide association analyses identify genotype-by-environment interactions of growth traits in Simmental cattle
por: Braz, Camila U., et al.
Publicado: (2021)

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways
por: Horgusluoglu-Moloch, Emrin, et al.
Publicado: (2019)

Genes and Pathways Affecting Sheep Productivity Traits: Genetic Parameters, Genome-Wide Association Mapping, and Pathway Enrichment Analysis
por: Esmaeili-Fard, Seyed Mehdi, et al.
Publicado: (2021)

CrusTome: a transcriptome database resource for large-scale analyses across Crustacea
por: Pérez-Moreno, Jorge L, et al.
Publicado: (2023)

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
por: Liang, Jingjing, et al.
Publicado: (2017)

Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations
por: Xiang, Ruidong, et al.
Publicado: (2021)

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses
por: Middleton, Lawrence, et al.
Publicado: (2022)

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data
por: Beck, Tim, et al.
Publicado: (2009)

Tracing Autism Traits in Large Multiplex Families to Identify Endophenotypes of the Broader Autism Phenotype
por: Trevis, Krysta J., et al.
Publicado: (2020)

Across-cohort QC analyses of GWAS summary statistics from complex traits
por: Chen, Guo-Bo, et al.
Publicado: (2017)

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
por: Liang, Jingjing, et al.
Publicado: (2018)

Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries
por: Smith, Samuel Pattillo, et al.
Publicado: (2022)

Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers
por: Hwang, Tae Hyun, et al.
Publicado: (2013)

Imputed gene associations identify replicable trans‐acting genes enriched in transcription pathways and complex traits
por: Wheeler, Heather E., et al.
Publicado: (2019)

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
por: Mancuso, Nicholas, et al.
Publicado: (2018)

Association analyses identify 31 new risk loci for colorectal cancer susceptibility
por: Law, Philip J., et al.
Publicado: (2019)

Modeling regulatory network topology improves genome-wide analyses of complex human traits
por: Zhu, Xiang, et al.
Publicado: (2021)

Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density
por: Wei, Jinsong, et al.
Publicado: (2016)

An extreme-phenotype genome‐wide association study identifies candidate cannabinoid pathway genes in Cannabis
por: Welling, Matthew T., et al.
Publicado: (2020)

Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain
por: Ao, Xiang, et al.
Publicado: (2023)

A shared genetic contribution to osteoarthritis and COVID-19 outcomes: a large-scale genome-wide cross-trait analysis
por: Huang, Yi-Xuan, et al.
Publicado: (2023)

Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity
por: Farris, Joseph, et al.
Publicado: (2020)

Genome-Wide Association Analyses of Fertility Traits in Beef Heifers
por: Stegemiller, Morgan R., et al.
Publicado: (2021)

A large-scale field experiment across six rivers illustrates how the effects of resource enrichment are context dependent
por: Bovill, William D., et al.
Publicado: (2023)

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function
por: Tang, Wenbo, et al.
Publicado: (2014)

Large-Scale Analyses of Glycosylation in Cellulases
por: Zhou, Fengfeng, et al.
Publicado: (2009)

Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease
por: Carbonetto, Peter, et al.
Publicado: (2013)

Large Scale Analysis of Phenotype-Pathway Relationships Based on GWAS Results
por: Brodie, Aharon, et al.
Publicado: (2014)

Genome-Wide Identification and Analysis of Enhancer-Regulated microRNAs Across 31 Human Cancers
por: Tang, Fei, et al.
Publicado: (2020)

Genome-wide analyses across Viridiplantae reveal the origin and diversification of small RNA pathway-related genes
por: Wang, Sibo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vomnibq771nt97g1609tnf39be