Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens

Sterile alpha motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) limits the efficacy of cytarabine (ara-C) used in AML by hydrolyzing its active metabolite ara-CTP and thus represents a promising therapeutic target. SAMHD1 has also been implicated in DNA damage repair that may im...

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Detalles Bibliográficos
Autores principales: Rassidakis, George Z., Herold, Nikolas, Myrberg, Ida Hed, Tsesmetzis, Nikolaos, Rudd, Sean G., Henter, Jan-Inge, Schaller, Torsten, Ng, Siok-Bian, Chng, Wee Joo, Yan, Benedict, Ng, Chin Hin, Ravandi, Farhad, Andreeff, Michael, Kantarjian, Hagop M., Medeiros, L. Jeffrey, Xagoraris, Ioanna, Khoury, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195559/
https://www.ncbi.nlm.nih.gov/pubmed/30341277
http://dx.doi.org/10.1038/s41408-018-0134-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195559/
https://www.ncbi.nlm.nih.gov/pubmed/30341277
http://dx.doi.org/10.1038/s41408-018-0134-z

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