TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

The mitotic checkpoint ensures accurate chromosome segregation through assembly of the mitotic checkpoint complex (MCC), a soluble inhibitor of the anaphase-promoting complex/cyclosome (APC/C) produced by unattached kinetochores. MCC is also assembled during interphase by Mad1/Mad2 bound at nuclear...

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Detalles Bibliográficos
Autores principales: Kim, Dong Hyun, Han, Joo Seok, Ly, Peter, Ye, Qiaozhen, McMahon, Moira A., Myung, Kyungjae, Corbett, Kevin D., Cleveland, Don W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195577/
https://www.ncbi.nlm.nih.gov/pubmed/30341343
http://dx.doi.org/10.1038/s41467-018-06774-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195577/
https://www.ncbi.nlm.nih.gov/pubmed/30341343
http://dx.doi.org/10.1038/s41467-018-06774-1

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