Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell survival and autophagy, and its activity is regulated by amino acid availability. Rag GTPase-GATOR1 interactions inhibit mTORC1 in the absence of amino acids, and GATOR1 release and activation of RagA/B promotes mTORC1 activity in...

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Detalles Bibliográficos
Autores principales: Pal, Rituraj, Palmieri, Michela, Chaudhury, Arindam, Klisch, Tiemo Jürgen, di Ronza, Alberto, Neilson, Joel R., Rodney, George G., Sardiello, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195609/
https://www.ncbi.nlm.nih.gov/pubmed/30341294
http://dx.doi.org/10.1038/s41467-018-06844-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195609/
https://www.ncbi.nlm.nih.gov/pubmed/30341294
http://dx.doi.org/10.1038/s41467-018-06844-4

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