Synergistic and independent action of endogenous microRNAs 122a and 199a for post-transcriptional liver detargeting of gene vectors

In hepatocellular carcinoma (HCC), which usually develops in a cirrhotic liver, treatments preserving normal liver function and viability are vitally important. Here, we utilise the differential expression of miRNAs 122a and 199a between normal hepatocytes and HCC to generate vectors harbouring thei...

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Detalles Bibliográficos
Autores principales: Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Steel, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195616/
https://www.ncbi.nlm.nih.gov/pubmed/30341383
http://dx.doi.org/10.1038/s41598-018-33801-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195616/
https://www.ncbi.nlm.nih.gov/pubmed/30341383
http://dx.doi.org/10.1038/s41598-018-33801-4

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