Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells

Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5′-phosphatase SHIP...

Descripción completa

Detalles Bibliográficos
Autores principales: Zorn, Carolin N., Simonowski, Anne, Huber, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195619/
https://www.ncbi.nlm.nih.gov/pubmed/30341350
http://dx.doi.org/10.1038/s41598-018-33769-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195619/
https://www.ncbi.nlm.nih.gov/pubmed/30341350
http://dx.doi.org/10.1038/s41598-018-33769-1

Ejemplares similares