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Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation
Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sort...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195632/ https://www.ncbi.nlm.nih.gov/pubmed/30242114 http://dx.doi.org/10.1042/BST20170432 |
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author | Wong, Louise H. Eden, Emily R. Futter, Clare E. |
author_facet | Wong, Louise H. Eden, Emily R. Futter, Clare E. |
author_sort | Wong, Louise H. |
collection | PubMed |
description | Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sorting of many cargos onto ILVs depends on the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, although ESCRT-independent mechanisms also exist. In mammalian cells, efficient sorting of ligand-stimulated epidermal growth factor receptors onto ILVs also depends on the tyrosine phosphatase, PTP1B, an ER-localised enzyme that interacts with endosomal targets at membrane contacts between MVBs and the ER. This review focuses on the potential roles played by ER:MVB membrane contact sites in regulating ESCRT-dependent ILV formation. |
format | Online Article Text |
id | pubmed-6195632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61956322018-10-30 Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation Wong, Louise H. Eden, Emily R. Futter, Clare E. Biochem Soc Trans Review Articles Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sorting of many cargos onto ILVs depends on the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, although ESCRT-independent mechanisms also exist. In mammalian cells, efficient sorting of ligand-stimulated epidermal growth factor receptors onto ILVs also depends on the tyrosine phosphatase, PTP1B, an ER-localised enzyme that interacts with endosomal targets at membrane contacts between MVBs and the ER. This review focuses on the potential roles played by ER:MVB membrane contact sites in regulating ESCRT-dependent ILV formation. Portland Press Ltd. 2018-10-19 2018-09-21 /pmc/articles/PMC6195632/ /pubmed/30242114 http://dx.doi.org/10.1042/BST20170432 Text en © 2018 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Articles Wong, Louise H. Eden, Emily R. Futter, Clare E. Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title | Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title_full | Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title_fullStr | Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title_full_unstemmed | Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title_short | Roles for ER:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
title_sort | roles for er:endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195632/ https://www.ncbi.nlm.nih.gov/pubmed/30242114 http://dx.doi.org/10.1042/BST20170432 |
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