Harnessing accurate non-homologous end joining for efficient precise deletion in CRISPR/Cas9-mediated genome editing

BACKGROUND: Many applications of CRISPR/Cas9-mediated genome editing require Cas9-induced non-homologous end joining (NHEJ), which was thought to be error prone. However, with directly ligatable ends, Cas9-induced DNA double strand breaks may be repaired preferentially by accurate NHEJ. RESULTS: In...

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Detalles Bibliográficos
Autores principales: Guo, Tao, Feng, Yi-Li, Xiao, Jing-Jing, Liu, Qian, Sun, Xiu-Na, Xiang, Ji-Feng, Kong, Na, Liu, Si-Cheng, Chen, Guo-Qiao, Wang, Yue, Dong, Meng-Meng, Cai, Zhen, Lin, Hui, Cai, Xiu-Jun, Xie, An-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195759/
https://www.ncbi.nlm.nih.gov/pubmed/30340517
http://dx.doi.org/10.1186/s13059-018-1518-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195759/
https://www.ncbi.nlm.nih.gov/pubmed/30340517
http://dx.doi.org/10.1186/s13059-018-1518-x

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