Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Detyrosinated microtubules (MTs) provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of MT detyrosination in heart failure or in human hearts have not previously been studied. Here we utilize mass spectrometry and single-myocyte mec...

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Detalles Bibliográficos
Autores principales: Yingxian Chen, Christina, Caporizzo, Matthew A., Bedi, Kenneth, Vite, Alexia, Bogush, Alexey I., Robison, Patrick, Heffler, Julie G., Salomon, Alex K., Kelly, Neil A., Babu, Apoorva, Morley, Michael P., Margulies, Kenneth B., Prosser, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195768/
https://www.ncbi.nlm.nih.gov/pubmed/29892068
http://dx.doi.org/10.1038/s41591-018-0046-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195768/
https://www.ncbi.nlm.nih.gov/pubmed/29892068
http://dx.doi.org/10.1038/s41591-018-0046-2

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