Cargando…

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Detyrosinated microtubules (MTs) provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of MT detyrosination in heart failure or in human hearts have not previously been studied. Here we utilize mass spectrometry and single-myocyte mec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yingxian Chen, Christina, Caporizzo, Matthew A., Bedi, Kenneth, Vite, Alexia, Bogush, Alexey I., Robison, Patrick, Heffler, Julie G., Salomon, Alex K., Kelly, Neil A., Babu, Apoorva, Morley, Michael P., Margulies, Kenneth B., Prosser, Benjamin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195768/ https://www.ncbi.nlm.nih.gov/pubmed/29892068 http://dx.doi.org/10.1038/s41591-018-0046-2

Ejemplares similares

Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
por: Salomon, Alexander K., et al.
Publicado: (2022)

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle
por: Kerr, Jaclyn P., et al.
Publicado: (2015)

Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes
por: Casini, S, et al.
Publicado: (2023)

Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure
por: Phyo, Sai Aung, et al.
Publicado: (2022)

Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level
Publicado: (1988)

Spatial and temporal colocalization of the Golgi apparatus and microtubules rich in detyrosinated tubulin
Publicado: (1990)

Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules
Publicado: (1987)

Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts
Publicado: (1995)

PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules
por: Kath, Christina, et al.
Publicado: (2018)

Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome–autophagosome fusion
por: Mohan, Nitin, et al.
Publicado: (2019)

MARK4 controls ischaemic heart failure through microtubule detyrosination
por: Yu, Xian, et al.
Publicado: (2021)

Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
por: Leibinger, Marco, et al.
Publicado: (2023)

Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers
por: Harriot, Anicca D., et al.
Publicado: (2023)

Cap-Gly Proteins at Microtubule Plus Ends: Is EB1 Detyrosination Involved?
por: Bosson, Anouk, et al.
Publicado: (2012)

INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells
por: Andrés-Delgado, Laura, et al.
Publicado: (2012)

Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration
por: Lavrsen, Kirstine, et al.
Publicado: (2023)

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
por: Herms, Albert, et al.
Publicado: (2015)

Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules
Publicado: (1987)

Suppression of tubulin detyrosination by parthenolide recruits the plant-specific kinesin KCH to cortical microtubules
por: Schneider, Natalie, et al.
Publicado: (2015)

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination
por: Yasuda, Kyota, et al.
Publicado: (2017)

Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design
por: Grignard, Jeremy, et al.
Publicado: (2022)

VASH1–SVBP and VASH2–SVBP generate different detyrosination profiles on microtubules
por: Ramirez-Rios, Sacnicte, et al.
Publicado: (2022)

Posttranslational modifications of alpha tubulin: detyrosination and acetylation differentiate populations of interphase microtubules in cultured cells
Publicado: (1988)

3299 Dynamic Afterload Cardiac Microtissue Model To Examine Molecular Pathways of Heart Failure
por: Ramachandran, Abhinay, et al.
Publicado: (2019)

Assembly and turnover of detyrosinated tubulin in vivo
Publicado: (1987)

Structural basis of tubulin detyrosination by vasohibins
por: Li, Faxiang, et al.
Publicado: (2019)

Microtubules orchestrate local translation to enable cardiac growth
por: Scarborough, Emily A., et al.
Publicado: (2021)

Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
por: Sharifi‐Sanjani, Maryam, et al.
Publicado: (2017)

3158 Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model
por: Livingston, Carissa, et al.
Publicado: (2019)

Tubulin detyrosination promotes human trophoblast syncytium formation
por: Wang, Rui, et al.
Publicado: (2019)

Structural insights into tubulin detyrosination by vasohibins-SVBP complex
por: Liu, Xi, et al.
Publicado: (2019)

Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness
por: Caporizzo, Matthew A., et al.
Publicado: (2021)

Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
por: Zhou, Chen, et al.
Publicado: (2019)

Hybrid Mathematical Model of Cardiomyocyte Turnover in the Adult Human Heart
por: Elser, Jeremy A., et al.
Publicado: (2012)

Detyrosination of alpha tubulin does not stabilize microtubules in vivo [published erratum appears in J Cell Biol 1990 Sep;111(3):1325-6]
Publicado: (1990)

Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model
por: Truitt, Rachel, et al.
Publicado: (2018)

Ultrastructural colocalization of tyrosinated and detyrosinated alpha- tubulin in interphase and mitotic cells
Publicado: (1986)

α-Tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicity
por: Lopes, Danilo, et al.
Publicado: (2022)

Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum
Publicado: (1987)

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease
por: Martínez-Hernández, José, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_92f5q7nbphmhthg8aae07t7qb5