Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer

Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we...

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Detalles Bibliográficos
Autores principales: Knickelbein, Kyle, Tong, Jingshan, Chen, Dongshi, Wang, Yi-Jun, Misale, Sandra, Bardelli, Alberto, Yu, Jian, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195818/
https://www.ncbi.nlm.nih.gov/pubmed/29755130
http://dx.doi.org/10.1038/s41388-018-0289-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195818/
https://www.ncbi.nlm.nih.gov/pubmed/29755130
http://dx.doi.org/10.1038/s41388-018-0289-x

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