Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways

BACKGROUND: Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial fragmentation and then investigated the downstream events that occurred in response to mitochondrial frag...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Jun, Cui, Jie, Wang, Lei, Wu, Kunpeng, Hong, Xiaoping, Zou, Yulin, Zhao, Shuang, Ke, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196464/
https://www.ncbi.nlm.nih.gov/pubmed/30377412
http://dx.doi.org/10.1186/s12935-018-0665-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196464/
https://www.ncbi.nlm.nih.gov/pubmed/30377412
http://dx.doi.org/10.1186/s12935-018-0665-1

Ejemplares similares