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Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways

BACKGROUND: Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial fragmentation and then investigated the downstream events that occurred in response to mitochondrial frag...

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Detalles Bibliográficos
Autores principales:	Wan, Jun, Cui, Jie, Wang, Lei, Wu, Kunpeng, Hong, Xiaoping, Zou, Yulin, Zhao, Shuang, Ke, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196464/ https://www.ncbi.nlm.nih.gov/pubmed/30377412 http://dx.doi.org/10.1186/s12935-018-0665-1

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