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NMDA-receptor antibodies alter cortical microcircuit dynamics

NMDA-receptor antibodies (NMDAR-Abs) cause an autoimmune encephalitis with a diverse range of EEG abnormalities. NMDAR-Abs are believed to disrupt receptor function, but how blocking this excitatory synaptic receptor can lead to paroxysmal EEG abnormalities—or even seizures—is poorly understood. Her...

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Detalles Bibliográficos
Autores principales: Rosch, Richard E., Wright, Sukhvir, Cooray, Gerald, Papadopoulou, Margarita, Goyal, Sushma, Lim, Ming, Vincent, Angela, Upton, A. Louise, Baldeweg, Torsten, Friston, Karl J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196513/
https://www.ncbi.nlm.nih.gov/pubmed/30262654
http://dx.doi.org/10.1073/pnas.1804846115