Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith–Magenis syndrome

Haploinsufficiency of Retinoic Acid Induced 1 (RAI1) causes Smith–Magenis syndrome (SMS), a syndromic autism spectrum disorder associated with craniofacial abnormalities, intellectual disability, and behavioral problems. There is currently no cure for SMS. Here, we generated a genetic mouse model to...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Hsiang, Wang, David C., Allen, William E., Klope, Matthew, Hu, Hailan, Shamloo, Mehrdad, Luo, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196530/
https://www.ncbi.nlm.nih.gov/pubmed/30275311
http://dx.doi.org/10.1073/pnas.1806796115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196530/
https://www.ncbi.nlm.nih.gov/pubmed/30275311
http://dx.doi.org/10.1073/pnas.1806796115

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