High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

Dysfunctional endothelium causes more disease than any other cell type. Systemically administered RNA delivery to nonliver tissues remains challenging, in large part because there is no high-throughput method to identify nanoparticles that deliver functional mRNA to cells in vivo. Here we report a s...

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Detalles Bibliográficos
Autores principales: Sago, Cory D., Lokugamage, Melissa P., Paunovska, Kalina, Vanover, Daryll A., Monaco, Christopher M., Shah, Nirav N., Gamboa Castro, Marielena, Anderson, Shannon E., Rudoltz, Tobi G., Lando, Gwyneth N., Munnilal Tiwari, Pooja, Kirschman, Jonathan L., Willett, Nick, Jang, Young C., Santangelo, Philip J., Bryksin, Anton V., Dahlman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196543/
https://www.ncbi.nlm.nih.gov/pubmed/30275336
http://dx.doi.org/10.1073/pnas.1811276115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196543/
https://www.ncbi.nlm.nih.gov/pubmed/30275336
http://dx.doi.org/10.1073/pnas.1811276115

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