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Perspective: A Novel Prognostic for Sickle Cell Disease
Sickle hemoglobin (α(2)β(S)(2)) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α(2)γ(2)) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-making relies on diagnostic technol...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196691/ https://www.ncbi.nlm.nih.gov/pubmed/30787839 http://dx.doi.org/10.4103/sjmms.sjmms_107_18 |