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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Mutations in PIK3CA, encoding the insulin-activated phosphoinositide-3-kinase (PI3K), and loss of function mutations in PTEN, a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among the most frequent events in human cancers(1,2). Yet, pharmacological inhibition of PI3K h...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197057/ https://www.ncbi.nlm.nih.gov/pubmed/30051890 http://dx.doi.org/10.1038/s41586-018-0343-4 |