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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation

BACKGROUND: Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical trials using retinoids for emphysema patients have failed. Crucial information about the specific role of RA sign...

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Detalles Bibliográficos
Autores principales: Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197151/
https://www.ncbi.nlm.nih.gov/pubmed/30236449
http://dx.doi.org/10.1016/j.ebiom.2018.09.002