Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing is reported to function in the nuclear factor-kappa B (NF-κB) signal pathway, but the regulatory mechanism remains elusive. Here we show that cyclophilin J (CYPJ),...

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Detalles Bibliográficos
Autores principales: Sheng, Chunjie, Yao, Chen, Wang, Ziyang, Chen, Hongyuan, Zhao, Yu, Xu, Dazhi, Huang, Haojie, Huang, Wenlin, Chen, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197184/
https://www.ncbi.nlm.nih.gov/pubmed/30348973
http://dx.doi.org/10.1038/s41467-018-06756-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197184/
https://www.ncbi.nlm.nih.gov/pubmed/30348973
http://dx.doi.org/10.1038/s41467-018-06756-3

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