Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

Over 160 mutations in superoxide dismutase 1 (SOD1) are associated with familial amyotrophic lateral sclerosis (fALS), where the main pathological feature is deposition of SOD1 into proteinaceous cytoplasmic inclusions. We previously showed that the tryptophan residue at position 32 (W32) mediates t...

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Detalles Bibliográficos
Autores principales: Pokrishevsky, Edward, McAlary, Luke, Farrawell, Natalie E., Zhao, Beibei, Sher, Mine, Yerbury, Justin J., Cashman, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197196/
https://www.ncbi.nlm.nih.gov/pubmed/30349065
http://dx.doi.org/10.1038/s41598-018-32835-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197196/
https://www.ncbi.nlm.nih.gov/pubmed/30349065
http://dx.doi.org/10.1038/s41598-018-32835-y

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