Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II

Heterozygous deletion of chromosome 17p (17p) is one of the most frequent genomic events in human cancers. Beyond the tumor suppressor TP53, the POLR2A gene encoding the catalytic subunit of RNA polymerase II (RNAP2) is also included in a ~20-megabase deletion region of 17p in 63% of metastatic cast...

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Detalles Bibliográficos
Autores principales: Li, Yujing, Liu, Yunhua, Xu, Hanchen, Jiang, Guanglong, Van der Jeught, Kevin, Fang, Yuanzhang, Zhou, Zhuolong, Zhang, Lu, Frieden, Michael, Wang, Lifei, Luo, Zhenhua, Radovich, Milan, Schneider, Bryan P., Deng, Yibin, Liu, Yunlong, Huang, Kun, He, Bin, Wang, Jin, He, Xiaoming, Zhang, Xinna, Ji, Guang, Lu, Xiongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197287/
https://www.ncbi.nlm.nih.gov/pubmed/30349055
http://dx.doi.org/10.1038/s41467-018-06811-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197287/
https://www.ncbi.nlm.nih.gov/pubmed/30349055
http://dx.doi.org/10.1038/s41467-018-06811-z

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