Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network

Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic. We propose the first mechanistic biophysical model for procentriole initiation which posits that int...

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Detalles Bibliográficos
Autores principales: Leda, Marcin, Holland, Andrew J., Goryachev, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197440/
https://www.ncbi.nlm.nih.gov/pubmed/30340068
http://dx.doi.org/10.1016/j.isci.2018.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197440/
https://www.ncbi.nlm.nih.gov/pubmed/30340068
http://dx.doi.org/10.1016/j.isci.2018.10.003

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