Structural insights into binding specificity, efficacy and bias of a β(2)AR partial agonist

Salmeterol is a partial agonist for the β(2) adrenergic receptor (β(2)AR), and the first long-acting β(2)AR agonist (LABA) to be widely used clinically for the treatment of asthma and chronic obstructive pulmonary disease. Salmeterol has been controversial both for its safety and mechanism of action...

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Detalles Bibliográficos
Autores principales: Masureel, Matthieu, Zou, Yaozhong, Picard, Louis-Philippe, van der Westhuizen, Emma, Mahoney, Jacob P., Rodrigues, João P.G.L.M., Mildorf, Thomas J., Dror, Ron O., Shaw, David E., Bouvier, Michel, Pardon, Els, Steyaert, Jan, Sunahara, Roger K., Weis, William I., Zhang, Cheng, Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197491/
https://www.ncbi.nlm.nih.gov/pubmed/30327561
http://dx.doi.org/10.1038/s41589-018-0145-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197491/
https://www.ncbi.nlm.nih.gov/pubmed/30327561
http://dx.doi.org/10.1038/s41589-018-0145-x

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