Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

There are several challenges towards the development and clinical use of small molecule inhibitors, which are currently the main type of targeted therapies towards intracellular proteins. PROteolysis-TArgeting Chimeras (PROTACs) exploit the intracellular ubiquitin-proteasome system to selectively de...

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Detalles Bibliográficos
Autores principales: An, Sainan, Fu, Liwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197674/
https://www.ncbi.nlm.nih.gov/pubmed/30224312
http://dx.doi.org/10.1016/j.ebiom.2018.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197674/
https://www.ncbi.nlm.nih.gov/pubmed/30224312
http://dx.doi.org/10.1016/j.ebiom.2018.09.005

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