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Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs
There are several challenges towards the development and clinical use of small molecule inhibitors, which are currently the main type of targeted therapies towards intracellular proteins. PROteolysis-TArgeting Chimeras (PROTACs) exploit the intracellular ubiquitin-proteasome system to selectively de...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197674/ https://www.ncbi.nlm.nih.gov/pubmed/30224312 http://dx.doi.org/10.1016/j.ebiom.2018.09.005 |