Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

OBJECTIVE: Mice with congenital loss of the glucagon receptor gene (Gcgr(−/−) mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomor...

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Detalles Bibliográficos
Autores principales: Rivero-Gutierrez, Belen, Haller, April, Holland, Jenna, Yates, Emily, Khrisna, Radha, Habegger, Kirk, Dimarchi, Richard, D'Alessio, David, Perez-Tilve, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197675/
https://www.ncbi.nlm.nih.gov/pubmed/30170980
http://dx.doi.org/10.1016/j.molmet.2018.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197675/
https://www.ncbi.nlm.nih.gov/pubmed/30170980
http://dx.doi.org/10.1016/j.molmet.2018.07.012

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