Cargando…

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

OBJECTIVE: Mice with congenital loss of the glucagon receptor gene (Gcgr(−/−) mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rivero-Gutierrez, Belen, Haller, April, Holland, Jenna, Yates, Emily, Khrisna, Radha, Habegger, Kirk, Dimarchi, Richard, D'Alessio, David, Perez-Tilve, Diego
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197675/ https://www.ncbi.nlm.nih.gov/pubmed/30170980 http://dx.doi.org/10.1016/j.molmet.2018.07.012

Ejemplares similares

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
por: Habegger, Kirk M., et al.
Publicado: (2013)

Hypothalamic Glucagon Receptors Regulate Feeding in Mice
por: Cunningham, Stephen E, et al.
Publicado: (2021)

OR28-5 Bile Acid Sequestration Accelerates Glucagon Receptor-Mediated Body Weight Loss in Obese Mice
por: Kim, Teayoun, et al.
Publicado: (2019)

Revisiting the Pharmacological Value of Glucagon: An Editorial for the Special Issue “The Biology and Pharmacology of Glucagon”
por: Müller, Timo D., et al.
Publicado: (2020)

GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats
por: Habegger, Kirk M., et al.
Publicado: (2013)

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats
por: Habegger, Kirk M., et al.
Publicado: (2014)

SAT-655 Bile Acid Sequestration Synergistically Accelerates Glucagon Receptor-Stimulated Body Weight Loss in Diet-Induced Obese Mice
por: Kim, Teayoun, et al.
Publicado: (2020)

Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances
por: Perez-Tilve, Diego
Publicado: (2020)

Glucagon Regulation of Energy Expenditure
por: Kleinert, Maximilian, et al.
Publicado: (2019)

Glucagon-like peptide 1 (GLP-1)
por: Müller, T.D., et al.
Publicado: (2019)

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
por: Knerr, Patrick J., et al.
Publicado: (2022)

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes
por: Nason, Shelly R., et al.
Publicado: (2021)

Taking Aim at Islet Hormones With GLP-1: Is Insulin or Glucagon the Better Target?
por: D'Alessio, David A.
Publicado: (2010)

Olfactory marker protein regulation of glucagon secretion in hyperglycemia
por: Oh, Ju Hun, et al.
Publicado: (2022)

A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia()
por: Chabenne, Joseph, et al.
Publicado: (2014)

Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery
por: Salehi, Marzieh, et al.
Publicado: (2014)

A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake
por: Holland, Jenna, et al.
Publicado: (2019)

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors
por: Heppner, Kristy M., et al.
Publicado: (2014)

Fibroblast activation protein (FAP) as a novel metabolic target
por: Sánchez-Garrido, Miguel Angel, et al.
Publicado: (2016)

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling
por: Lockie, Sarah H., et al.
Publicado: (2012)

Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice
por: Zhong, Ying, et al.
Publicado: (2020)

Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
por: Capozzi, Megan E, et al.
Publicado: (2018)

Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia
por: Tan, Tricia M., et al.
Publicado: (2013)

Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans
por: Salehi, Marzieh, et al.
Publicado: (2011)

Sitagliptin Improves Postprandial Hyperglycemia by Inhibiting Glucagon Secretion in Werner Syndrome With Diabetes
por: Watanabe, Kaneyuki, et al.
Publicado: (2013)

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
por: Knudsen, Jakob G., et al.
Publicado: (2019)

Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice
por: Habegger, Kirk M., et al.
Publicado: (2011)

GLP-1/glucagon receptor co-agonism for treatment of obesity
por: Sánchez-Garrido, Miguel A., et al.
Publicado: (2017)

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
por: Sandoval, Darleen A., et al.
Publicado: (2008)

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance
por: Habegger, Kirk M., et al.
Publicado: (2012)

Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats
por: Barrera, Jason G., et al.
Publicado: (2009)

The ubiquitination status of the glucagon receptor determines signal bias
por: Kaur, Suneet, et al.
Publicado: (2023)

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
por: Mroz, Piotr A., et al.
Publicado: (2018)

Caloric Restriction Chronically Impairs Metabolic Programming in Mice
por: Kirchner, Henriette, et al.
Publicado: (2012)

Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis
por: Tiano, Joseph P., et al.
Publicado: (2015)

Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor
por: Douros, Jonathan D., et al.
Publicado: (2018)

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
por: Wilson-Pérez, Hilary E., et al.
Publicado: (2013)

Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice
por: Yang, Yuqing, et al.
Publicado: (2010)

Glucagon Like Peptide-1-Induced Glucose Metabolism in Differentiated Human Muscle Satellite Cells Is Attenuated by Hyperglycemia
por: Green, Charlotte J., et al.
Publicado: (2012)

NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
por: Sheng, Liang, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n6or8nj8al9o7b1k1arpiogpjn