Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function

The cardiac muscarinic receptor (M2R) regulates heart rate, in part, by modulating the acetylcholine (ACh) activated K(+) current I(K,ACh) through dissociation of G-proteins, that in turn activate K(ACh) channels. Recently, M2Rs were noted to exhibit intrinsic voltage sensitivity, i.e. their affinit...

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Detalles Bibliográficos
Autores principales: Moss, Robin, Sachse, Frank B., Moreno-Galindo, Eloy G., Navarro-Polanco, Ricardo A., Tristani-Firouzi, Martin, Seemann, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197694/
https://www.ncbi.nlm.nih.gov/pubmed/30303952
http://dx.doi.org/10.1371/journal.pcbi.1006438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197694/
https://www.ncbi.nlm.nih.gov/pubmed/30303952
http://dx.doi.org/10.1371/journal.pcbi.1006438

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