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Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function
The cardiac muscarinic receptor (M2R) regulates heart rate, in part, by modulating the acetylcholine (ACh) activated K(+) current I(K,ACh) through dissociation of G-proteins, that in turn activate K(ACh) channels. Recently, M2Rs were noted to exhibit intrinsic voltage sensitivity, i.e. their affinit...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197694/ https://www.ncbi.nlm.nih.gov/pubmed/30303952 http://dx.doi.org/10.1371/journal.pcbi.1006438 |